Back to Search
Start Over
Chicken anaemia virus enhances and prolongs subsequent avian influenza (H9N2) and infectious bronchitis viral infections.
- Source :
-
Veterinary microbiology [Vet Microbiol] 2019 Mar; Vol. 230, pp. 123-129. Date of Electronic Publication: 2019 Feb 02. - Publication Year :
- 2019
-
Abstract
- Immunosuppressive viral diseases have a great economic importance in the poultry industry due to the increased susceptibility to secondary infections. Chicken anaemia virus (CAV) is one of the major immunosuppressive diseases in chickens. In addition, low pathogenic avian influenza (LPAI) of subtype H9N2 and infectious bronchitis (IB) viruses are among the most frequently reported respiratory viral diseases in poultry worldwide. In the present study, specific pathogen free chickens were used to understand the impact of CAV on secondary infection with LPAI-H9N2 or IB viruses. Clinical outcomes, viral shedding dynamics, and cytokine levels wereassessed. The results exhibit that chickens previously infected with CAV produceconsiderablyhigher titresof LPAI-H9N2 or IB viruses in the oropharyngeal swabs (P < 0.05), tracheas and kidneys. In addition, the immunologic effect of CAV provokedthe development of clinical signs of LPAI-H9N2 and IB virus infections. Moreover, results suggested that pre-infection with CAV directly correlated with elevated levels of IL-6 and IFNγ. These findings underline the importance of CAV pre-infection on LPAI-H9N2 or IB infection in chickens, and indicate that co-circulation of CAV can contribute to the spread and evolution of LPAI H9N2 and IB viruses.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Chicken anemia virus immunology
Chickens virology
Circoviridae Infections immunology
Coinfection immunology
Coinfection virology
Coronavirus Infections immunology
Cytokines blood
Infectious bronchitis virus immunology
Influenza A Virus, H9N2 Subtype
Poultry Diseases immunology
Specific Pathogen-Free Organisms
Virus Shedding
Circoviridae Infections veterinary
Coinfection veterinary
Coronavirus Infections veterinary
Influenza in Birds immunology
Poultry Diseases virology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2542
- Volume :
- 230
- Database :
- MEDLINE
- Journal :
- Veterinary microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 30827377
- Full Text :
- https://doi.org/10.1016/j.vetmic.2019.01.024