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The preparation and morphology control of heparin-based pH sensitive polyion complexes and their application as drug carriers.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2019 May 01; Vol. 211, pp. 370-379. Date of Electronic Publication: 2019 Feb 10. - Publication Year :
- 2019
-
Abstract
- Heparin as negative polysaccharide is a universal building block to form polyion complex with different cationic counterparts. In this paper, three different cations, including chitosan, benzyldodecyldimethyl ammonium bromide and doxorubicin hydrochloride, were used to prepare heparin-based polyion complexes (HPICs). Their morphologies could be tuned by heparin content in HPIC, and they also showed pH-sensitive decomposition. Doxorubicin was further encapsulated into micelle and vesicle carrier made from heparin-benzyldodecyl dimethyl ammonium bromide PIC, whereas heparin-doxorubicin PIC could be directly used as drug carrier. In vitro drug release proved the drug carriers exhibit obvious pH sensitive release behaviour. Cytotoxicity indicated the drug carrier possessed significant cytotoxicity to tumor cells. The cell uptake observed by CLSM showed the carrier was able to deliver antitumor drug into tumor cell's nucleus. Consequently, these results showed the promising potential of HPIC in drug carrier application.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antibiotics, Antineoplastic administration & dosage
Antibiotics, Antineoplastic chemistry
Benzalkonium Compounds administration & dosage
Benzalkonium Compounds chemistry
Biological Transport
Cell Line, Tumor
Cell Survival drug effects
Chitosan administration & dosage
Chitosan chemistry
Doxorubicin administration & dosage
Doxorubicin chemistry
Drug Liberation
Humans
Hydrogen-Ion Concentration
Micelles
Drug Carriers administration & dosage
Drug Carriers chemistry
Heparin administration & dosage
Heparin chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 211
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 30824101
- Full Text :
- https://doi.org/10.1016/j.carbpol.2019.01.089