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Developing a Core Outcome Set for Cesarean Delivery Maternal Infectious Morbidity Outcomes.
- Source :
-
American journal of perinatology [Am J Perinatol] 2020 Mar; Vol. 37 (4), pp. 436-452. Date of Electronic Publication: 2019 Feb 28. - Publication Year :
- 2020
-
Abstract
- Objective: This study aimed to develop a core outcome set of primary outcomes for studies involving cesarean deliveries with infectious morbidity outcomes.<br />Study Design: Authors reported primary outcomes from 11 Cochrane systematic reviews (SRs), 12 other SRs, and 327 randomized controlled trials (RCTs). These outcomes were condensed into 20 primary outcome groups. Next, a modified Delphi technique was used to gain consensus on key outcomes. Authors from included SRs were sent a questionnaire consisting of a free response and multiple-choice questions. These data were used to propose a set of core outcomes.<br />Results: The most frequent outcomes in RCTs were composite "infectious outcomes" (24%) with the second most common being endometritis (12%). The most common reported SR outcomes were wound infection (21%) and endometritis (16%). For the Delphi survey free response portion, wound infection (88%) and endometritis (79%) were the most commonly endorsed outcomes. Chosen list outcomes were maternal mortality (83%), wound infection (83%), wound complications (86%), and postpartum endometritis (80%). The proposed final core outcome set for cesarean trials was endometritis (primary outcome), maternal mortality, wound infection, wound complications, febrile morbidity, and neonatal morbidity.<br />Conclusion: Utilizing defined core outcomes in all studies of cesarean section can harmonize trial reports and allow data synthesis for meta-analyses.<br />Competing Interests: None declared.<br /> (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
- Subjects :
- Anti-Bacterial Agents therapeutic use
Antibiotic Prophylaxis
Delphi Technique
Female
Fever etiology
Humans
Infant, Newborn
Male
Neonatal Sepsis etiology
Pregnancy
Systematic Reviews as Topic
Cesarean Section adverse effects
Endometritis etiology
Puerperal Disorders etiology
Puerperal Infection etiology
Surgical Wound Infection etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-8785
- Volume :
- 37
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of perinatology
- Publication Type :
- Academic Journal
- Accession number :
- 30818401
- Full Text :
- https://doi.org/10.1055/s-0039-1681095