Back to Search
Start Over
Central serous chorioretinopathy with and without steroids: A multicenter survey.
- Source :
-
PloS one [PLoS One] 2019 Feb 28; Vol. 14 (2), pp. e0213110. Date of Electronic Publication: 2019 Feb 28 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- We investigated the rates of the use of steroids in Japanese central serous chorioretinopathy (CSC) cases and differences in the characteristics of CSC with and without steroids. A total of 538 eyes of 477 patients diagnosed with CSC, with 3 months or more of follow-up between April 2013 and June 2017 at 8 institutions. Patients with CSC with more than 3 months of follow-up were identified by OCT and fluorescein angiography at 8 institutions. Data collected included patient demographics, history of corticosteroid medication and smoking, spherical errors, findings of angiography, subfoveal choroidal thickness, and changes through the follow-up period. Differences in these findings were analyzed in cases with and without corticosteroid treatment. Among the 477 patients (344 men,133 women), 74 (15.5%) (39 men, 35 women) underwent current or prior steroid treatment. Cases with steroids were higher age (p = 0.0403) and showed no male prevalence, more bilateral involvement (p < 0.0001), and the affected eyes had multiple pigment epithelial detachment (p <0.0001), more fluorescein leakage sites (p < 0.0001), greater choroidal thickness (p = 0.0287) and a higher recurrence rate (p = 0.0412). Steroids can cause severer CSC through an effect on choroidal vessels and an impairment of retinal pigment epithelium.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Adult
Aged
Aged, 80 and over
Central Serous Chorioretinopathy chemically induced
Central Serous Chorioretinopathy diagnosis
Choroid blood supply
Choroid drug effects
Female
Fluorescein Angiography
Follow-Up Studies
Humans
Japan
Male
Middle Aged
Retinal Detachment chemically induced
Retinal Detachment diagnosis
Retinal Detachment etiology
Retinal Pigment Epithelium drug effects
Retrospective Studies
Risk Factors
Surveys and Questionnaires
Tomography, Optical Coherence
Adrenal Cortex Hormones adverse effects
Central Serous Chorioretinopathy etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 30818363
- Full Text :
- https://doi.org/10.1371/journal.pone.0213110