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Post-esophagectomy Adjuvant Chemotherapy Benefits Esophageal Cancer Patients.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 2019 Mar-Apr; Vol. 33 (2), pp. 501-506. - Publication Year :
- 2019
-
Abstract
- Background/aim: Postoperative chemotherapy is an absolutely imperative treatment for advanced esophageal cancer patients, while preoperative chemotherapy is the standard therapy for clinical stage II/III esophageal squamous cell carcinoma (ESCC) in Japan. The aim of this study was to report the effect of postoperative chemotherapy on survival after esophagectomy due to thoracic esophageal squamous cell carcinoma.<br />Patients and Methods: One hundred thirteen consecutive patients with esophageal carcinoma who underwent esophagectomy were included. Several regiments were performed at various times.<br />Results: Adjuvant chemotherapy brought a significantly superior overall survival (p=0.002), although there was no significant difference in cancer-specific survival (p=0.054) for clinical stage II or stage III esophageal cancer patients. Depth of invasion (p=0.003), number of lymph node metastases (p=0.048), and venous invasion (p<0.001) were risk factors for recurrence in the adjuvant-chemotherapy group with positive lymph nodes. Additionally, a not well-differentiated type, lymphatic and venous invasions were risk factors for recurrence in the surgery-alone group without positive lymph nodes.<br />Conclusion: Postoperative adjuvant chemotherapy contributes to the prognosis of clinical stage II or III esophageal cancer patients.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Aged
Chemotherapy, Adjuvant methods
Cisplatin administration & dosage
Combined Modality Therapy
Disease-Free Survival
Esophageal Neoplasms pathology
Esophageal Neoplasms surgery
Esophageal Squamous Cell Carcinoma pathology
Esophageal Squamous Cell Carcinoma surgery
Esophagectomy
Female
Fluorouracil administration & dosage
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis
Male
Neoplasm Recurrence, Local pathology
Neoplasm Recurrence, Local surgery
Neoplasm Staging
Esophageal Neoplasms drug therapy
Esophageal Squamous Cell Carcinoma drug therapy
Neoplasm Recurrence, Local drug therapy
Prognosis
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7549
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 30804133
- Full Text :
- https://doi.org/10.21873/invivo.11502