A Nationwide Screen of Carbapenem-Resistant Klebsiella pneumoniae Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance.

Authors :: Wozniak JE
Band VI
Conley AB
Rishishwar L
Burd EM
Satola SW
Hardy DJ
Tsay R
Farley MM
Jacob JT
Dumyati G
Jordan IK
Weiss DS
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Apr 25; Vol. 63 (5). Date of Electronic Publication: 2019 Apr 25 (Print Publication: 2019).
Publication Year :: 2019
Abstract: The convergence of hypervirulence and multidrug resistance in Klebsiella pneumoniae is a significant concern. Here, we report the first screen for hypermucoviscosity, a trait associated with increased virulence, using a U.S. surveillance collection of carbapenem-resistant (CR) K. pneumoniae isolates. We identified one hypermucoviscous isolate, which carried a gene encoding the KPC-3 carbapenemase, among numerous resistance genes. The strain further exhibited colistin heteroresistance undetected by diagnostics. This convergence of diverse resistance mechanisms and increased virulence underscores the need for enhanced K. pneumoniae surveillance.<br /> (Copyright © 2019 American Society for Microbiology.)

Subjects :: Carbapenem-Resistant Enterobacteriaceae drug effects
Drug Resistance, Bacterial genetics
Genotype
Klebsiella pneumoniae drug effects
Klebsiella pneumoniae genetics
Microbial Sensitivity Tests
Virulence
Carbapenem-Resistant Enterobacteriaceae genetics
Carbapenems pharmacology
Colistin pharmacology

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