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Pd/Cu-Catalyzed Cascade C(sp 3 )-H Arylation and Intramolecular C-N Coupling: A One-Pot Synthesis of 3,4-2 H-Quinolinone Skeletons.
- Source :
-
Organic letters [Org Lett] 2019 Mar 15; Vol. 21 (6), pp. 1668-1671. Date of Electronic Publication: 2019 Feb 25. - Publication Year :
- 2019
-
Abstract
- In this letter, we successfully explored a cascade Pd/Cu-catalyzed intermolecular C(sp <superscript>3</superscript> )-H arylation of amides and intramolecular C-N coupling reaction. This method provides a one-pot strategy to synthesize 3,4-2 H-quinolinone with good regioselectivity of C-H arylation and C-N coupling from C-I and C-X bonds from readily available starting materials.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 21
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 30801191
- Full Text :
- https://doi.org/10.1021/acs.orglett.9b00214