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Effects of sulindac and ibuprofen in patients with cirrhosis and ascites. An explanation for the renal-sparing effect of sulindac.
- Source :
-
Gastroenterology [Gastroenterology] 1986 Jan; Vol. 90 (1), pp. 182-7. - Publication Year :
- 1986
-
Abstract
- Nonsteroidal antiinflammatory drugs impair renal function in susceptible patients with cirrhosis and ascites. A new antiinflammatory drug, sulindac, is reported not to affect renal function. To evaluate its renal-sparing mechanism, sulindac was administered for 5 days and ibuprofen for 1 day to 10 patients and paraaminohippurate and inulin clearances, serum and urine eicosanoids, and serum and urine sulindac metabolites were monitored. Ibuprofen reduced renal clearances in the 5 subjects with greatest sodium retention, whereas sulindac had no effect. Plasma concentration of the active sulfide metabolite was markedly increased in liver patients, and this concentration correlated with the inhibition of serum thromboxane (r = 0.75, p = 0.01). The percent inhibition of serum thromboxane with sulindac administration correlated with the inhibition of urinary eicosanoids (r = 0.68-0.81, all p less than 0.02). Ibuprofen was generally a more potent inhibitor of serum and urine eicosanoids. Thus, a major factor in the renal-sparing effect of sulindac appears to be its less potent inhibition of renal and extrarenal cyclooxygenase systems.
- Subjects :
- 6-Ketoprostaglandin F1 alpha urine
Adult
Cyclooxygenase Inhibitors
Dinoprostone
Humans
Ibuprofen toxicity
Kidney metabolism
Kidney Function Tests
Middle Aged
Prostaglandins E urine
Renal Circulation drug effects
Sulindac toxicity
Thromboxane B2 metabolism
Time Factors
Ibuprofen therapeutic use
Indenes therapeutic use
Kidney drug effects
Liver Cirrhosis, Alcoholic drug therapy
Sulindac therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0016-5085
- Volume :
- 90
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 3079594
- Full Text :
- https://doi.org/10.1016/0016-5085(86)90091-0