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A Brief Review on New Naturally Occurring Cembranoid Diterpene Derivatives from the Soft Corals of the Genera Sarcophyton , Sinularia , and Lobophytum Since 2016.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2019 Feb 21; Vol. 24 (4). Date of Electronic Publication: 2019 Feb 21. - Publication Year :
- 2019
-
Abstract
- This work reviews the new isolated cembranoid derivatives from species of the genera Sarcophyton , Sinularia , and Lobophytum as well as their biological properties, during 2016⁻2018. The compilation permitted to conclude that much more new cembranoid diterpenes were found in the soft corals of the genus Sarcophyton than in those belonging to the genera Lobophytum or Sinularia . Beyond the chemical composition, the biological properties were also reviewed, namely anti-microbial against several Gram-positive and Gram-negative bacteria and fungi, anti-inflammatory and anti-tumoral against several types of cancer cells. In spite of the biological activities detected in almost all samples, there is a remarkable diversity in the results which may be attributed to the chemical variability that needs to be deepened in order to develop new molecules with potential application in medicine.
- Subjects :
- Animals
Anthozoa metabolism
Anti-Bacterial Agents classification
Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Anti-Inflammatory Agents classification
Anti-Inflammatory Agents isolation & purification
Anti-Inflammatory Agents pharmacology
Antifungal Agents classification
Antifungal Agents isolation & purification
Antifungal Agents pharmacology
Antineoplastic Agents classification
Antineoplastic Agents isolation & purification
Antineoplastic Agents pharmacology
Bacteria drug effects
Bacteria growth & development
Cell Line, Tumor
Cell Survival drug effects
Diterpenes classification
Diterpenes isolation & purification
Diterpenes pharmacology
Fungi drug effects
Fungi growth & development
Humans
Inhibitory Concentration 50
Microbial Sensitivity Tests
Structure-Activity Relationship
Anthozoa chemistry
Anti-Bacterial Agents chemistry
Anti-Inflammatory Agents chemistry
Antifungal Agents chemistry
Antineoplastic Agents chemistry
Diterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 24
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 30795596
- Full Text :
- https://doi.org/10.3390/molecules24040781