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Effects of empagliflozin treatment on cardiac function and structure in patients with type 2 diabetes: a cardiac magnetic resonance study.
- Source :
-
Internal medicine journal [Intern Med J] 2019 Aug; Vol. 49 (8), pp. 1006-1010. - Publication Year :
- 2019
-
Abstract
- Background: The effects of empagliflozin on cardiac structure and function are not known.<br />Aims: To examine the changes in cardiac structure and function following the addition of empagliflozin in patients with type 2 (T2D) diabetes using cardiac magnetic resonance (CMR) imaging.<br />Methods: Twenty patients attending a specialist diabetes service recommended for treatment with empagliflozin, and 8 control patients with T2D on stable glucose lowering therapy were recruited for cardiac imaging. Participants underwent CMR scans at baseline and 6 months. Inclusion criteria were established T2D, age < 75 years, estimated glomerular filtration rate ≥45 mL/min/1.73 m <superscript>2</superscript> .<br />Results: 17 of 20 in the empagliflozin group, and all of 8 in the control group completed the study. Empagliflozin therapy was associated with reduction in left ventricular end diastolic volume 155 mL (137 mL, 174 mL) at baseline to 145 mL (125 mL, 165 mL) at 6 months, P < 0.01, compared with the control group 153 mL (128 mL, 179 mL) at baseline and 158 mL (128 mL, 190 mL), not significant. There were no differences in measures of left ventricular mass, ejection fraction, heart rate or markers of cardiac fibrosis at baseline and 6 months in either group.<br />Conclusions: This is the first CMR study to examine the effects of empagliflozin on cardiac function and structure, showing evidence of reduced end diastolic volume. This is likely to reflect change in plasma volume, and may explain the reduced cardiovascular death and heart failure seen in the EMPA-REG OUTCOME trial.<br /> (© 2019 Royal Australasian College of Physicians.)
- Subjects :
- Aged
Cohort Studies
Diabetes Mellitus, Type 2 blood
Female
Glomerular Filtration Rate
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Treatment Outcome
Benzhydryl Compounds therapeutic use
Diabetes Mellitus, Type 2 drug therapy
Glucosides therapeutic use
Heart diagnostic imaging
Heart drug effects
Sodium-Glucose Transporter 2 Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1445-5994
- Volume :
- 49
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Internal medicine journal
- Publication Type :
- Academic Journal
- Accession number :
- 30784160
- Full Text :
- https://doi.org/10.1111/imj.14260