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Increased vein wall thickness in Behçet disease.
- Source :
-
Journal of vascular surgery. Venous and lymphatic disorders [J Vasc Surg Venous Lymphat Disord] 2019 Sep; Vol. 7 (5), pp. 677-684.e2. Date of Electronic Publication: 2019 Feb 15. - Publication Year :
- 2019
-
Abstract
- Objective: Lower extremity (LE) deep venous thrombosis (DVT) is the main feature of vascular involvement in Behçet disease (BD). We thought that vein wall thickness (VWT) could be a surrogate marker for venous inflammation and hence predict future vascular involvement. We assessed VWT in proximal LE veins in BD patients without DVT, BD patients with DVT, and healthy controls in a formal, masked protocol.<br />Methods: We studied 50 (43 male and 7 female) BD patients with LE DVT (group 1), 50 (43 male and 7 female) BD patients without any vascular involvement (group 2), and 50 (43 male and 7 female) age- and sex-matched apparently healthy controls (group 3). Two radiologists blinded to the diagnosis of BD used ultrasound to measure VWT of common femoral vein, femoral vein, and great saphenous vein in both legs. Interobserver reliability was assessed using the intraclass correlation coefficient and Bland-Altman plots.<br />Results: There was good agreement between the two observers. The mean VWT was significantly increased in both BD patients with LE DVT and those without apparent vascular involvement compared with the healthy controls, whereas those with LE DVT had the highest VWT.<br />Conclusions: VWT of proximal deep and superficial LE veins is increased among the BD patients without any clinical and radiologic vascular involvement. This information, after prospective work, might be useful in management and elucidating disease mechanisms in vascular BD.<br /> (Copyright © 2019 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Behcet Syndrome diagnosis
Female
Humans
Male
Middle Aged
Observer Variation
Predictive Value of Tests
Reproducibility of Results
Retrospective Studies
Venous Thrombosis etiology
Behcet Syndrome complications
Femoral Vein diagnostic imaging
Saphenous Vein diagnostic imaging
Ultrasonography, Doppler
Venous Thrombosis diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2213-3348
- Volume :
- 7
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of vascular surgery. Venous and lymphatic disorders
- Publication Type :
- Academic Journal
- Accession number :
- 30777674
- Full Text :
- https://doi.org/10.1016/j.jvsv.2018.11.006