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Increased proportions of γδ T lymphocytes in atypical SCID associate with disease manifestations.
- Source :
-
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2019 Apr; Vol. 201, pp. 30-34. Date of Electronic Publication: 2019 Feb 15. - Publication Year :
- 2019
-
Abstract
- Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of γδ T lymphocytes have been reported. However, it is unknown whether these γδ T cells modulate or reflect the patient's clinical phenotype. We investigated the frequency of elevated γδ T cell proportions and associations with clinical disease manifestations in a cohort of 76 atypical SCID patients. Increased proportions of γδ T lymphocytes were present in approximately 60% of these patients. Furthermore, we identified positive correlations between elevated proportions of γδ T cells and the occurrence of CMV infections and autoimmune cytopenias. We discuss that CMV infections might trigger an expansion of γδ T lymphocytes, which could drive the development of autoimmune cytopenias. We advocate that atypical SCID patients should be screened for elevated proportions of γδ T lymphocytes, CMV infection and autoimmune cytopenias.<br /> (Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1521-7035
- Volume :
- 201
- Database :
- MEDLINE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 30776520
- Full Text :
- https://doi.org/10.1016/j.clim.2018.11.006