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Acute multiple sclerosis lesion pathology does not predict subsequent clinical course-a biopsy study.
- Source :
-
Irish journal of medical science [Ir J Med Sci] 2019 Nov; Vol. 188 (4), pp. 1427-1434. Date of Electronic Publication: 2019 Feb 15. - Publication Year :
- 2019
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Abstract
- Background: Knowledge of the clinical outcome in tumefactive demyelination remains limited.<br />Aims: This study aims to characterise the natural history of biopsy-proven, pathogen-free, cerebral demyelination in an adult Irish population.<br />Methods: We identified all patients with biopsy-proven demyelination in a single neuropathology centre between 1999 and 2017. A baseline, and at least one follow-up MRI scan was available in each instance (mean of 3 scans per patient), together with both the presenting and most recent clinical details including disability level and disease-modifying drugs.<br />Results: In 21 patients, white matter biopsies showed the following: macrophages with myelin debris, myelin-axonal dissociation, reactive astrocytes and occasional lymphocytes. During a mean follow-up time of 8 years (± 4.4), 17 patients developed MS, confirmed both clinically and on MRI, using the 2010 McDonald criteria: 11 relapsing remitting (RR) MS, four secondary progressive and two primary progressive MS. Four patients had a monophasic illness with lesion regression, without clinical or radiological evidence of any further disease activity on follow-up. The patients with progressive MS had significantly higher levels of physical disability than either the RRMS or monophasic patients.<br />Conclusion: Uniform white matter subacute demyelination is associated with a diverse clinical course ranging from a monophasic illness to progressive MS, suggesting that extraneous factors distinct from the basic pathology significantly influence the clinical course in MS.
Details
- Language :
- English
- ISSN :
- 1863-4362
- Volume :
- 188
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Irish journal of medical science
- Publication Type :
- Academic Journal
- Accession number :
- 30771138
- Full Text :
- https://doi.org/10.1007/s11845-019-01983-z