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Immunoglobulin G and Subclasses as Potential Biomarkers in Metastatic Melanoma Patients Starting Checkpoint Inhibitor Treatment.
- Source :
-
Journal of immunotherapy (Hagerstown, Md. : 1997) [J Immunother] 2019 Apr; Vol. 42 (3), pp. 89-93. - Publication Year :
- 2019
-
Abstract
- Checkpoint inhibitors have improved survival of metastatic melanoma. However, reliable biomarkers to predict response are still needed. Immunoglobulin G (IgG) antibody subclasses reflect immunocompetence in individuals and are known to be involved in essential functions in our immune system. This prospective study evaluated the association between serum IgG with its subclasses IgG1, IgG2, IgG3, and IgG4 and antitumor response according to RECIST 1.1. Serum samples from 49 patients were prospectively collected before the start of treatment with a checkpoint inhibitor. We observed a statistically significant association of baseline IgG2 with response to therapy (P=0.011). After defining optimal cutpoints, we found significant associations between total IgG (>9.66 g/L, P=0.038), IgG1 (>6.22 g/L, P=0.025), IgG2 (>2.42 g/L, P=0.019), and IgG3 (>0.21 g/L, P=0.034) with progression-free survival. Prolonged overall survival was associated with elevated IgG2 (>2.42 g/L, P=0.043). Together, these findings define total IgG and subclasses as predictors of clinical successful checkpoint inhibition in metastatic melanoma patients.
- Subjects :
- Adult
Aged
Aged, 80 and over
CTLA-4 Antigen antagonists & inhibitors
Female
Humans
Male
Melanoma mortality
Middle Aged
Neoplasm Metastasis
Patient Selection
Programmed Cell Death 1 Receptor antagonists & inhibitors
Prospective Studies
Survival Analysis
Antineoplastic Agents, Immunological therapeutic use
Biomarkers, Tumor blood
Immunoglobulin G blood
Immunotherapy methods
Melanoma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1537-4513
- Volume :
- 42
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of immunotherapy (Hagerstown, Md. : 1997)
- Publication Type :
- Academic Journal
- Accession number :
- 30768543
- Full Text :
- https://doi.org/10.1097/CJI.0000000000000255