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Subcortical electrophysiological activity is detectable with high-density EEG source imaging.
- Source :
-
Nature communications [Nat Commun] 2019 Feb 14; Vol. 10 (1), pp. 753. Date of Electronic Publication: 2019 Feb 14. - Publication Year :
- 2019
-
Abstract
- Subcortical neuronal activity is highly relevant for mediating communication in large-scale brain networks. While electroencephalographic (EEG) recordings provide appropriate temporal resolution and coverage to study whole brain dynamics, the feasibility to detect subcortical signals is a matter of debate. Here, we investigate if scalp EEG can detect and correctly localize signals recorded with intracranial electrodes placed in the centromedial thalamus, and in the nucleus accumbens. Externalization of deep brain stimulation (DBS) electrodes, placed in these regions, provides the unique opportunity to record subcortical activity simultaneously with high-density (256 channel) scalp EEG. In three patients during rest with eyes closed, we found significant correlation between alpha envelopes derived from intracranial and EEG source reconstructed signals. Highest correlation was found for source signals in close proximity to the actual recording sites, given by the DBS electrode locations. Therefore, we present direct evidence that scalp EEG indeed can sense subcortical signals.
- Subjects :
- Brain diagnostic imaging
Brain physiopathology
Brain Mapping
Deep Brain Stimulation methods
Electrodes
Electroencephalography instrumentation
Humans
Intralaminar Thalamic Nuclei diagnostic imaging
Intralaminar Thalamic Nuclei physiopathology
Magnetic Resonance Imaging
Nucleus Accumbens diagnostic imaging
Nucleus Accumbens physiopathology
Obsessive-Compulsive Disorder diagnostic imaging
Obsessive-Compulsive Disorder physiopathology
Obsessive-Compulsive Disorder therapy
Scalp diagnostic imaging
Scalp physiology
Scalp physiopathology
Tomography, X-Ray Computed
Tourette Syndrome diagnostic imaging
Tourette Syndrome physiopathology
Tourette Syndrome therapy
Brain physiology
Electroencephalography methods
Electrophysiological Phenomena
Intralaminar Thalamic Nuclei physiology
Nucleus Accumbens physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 30765707
- Full Text :
- https://doi.org/10.1038/s41467-019-08725-w