Back to Search
Start Over
Evaluation of a Novel Pb-203-Labeled Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptide for Melanoma Targeting.
- Source :
-
Molecular pharmaceutics [Mol Pharm] 2019 Apr 01; Vol. 16 (4), pp. 1694-1702. Date of Electronic Publication: 2019 Feb 25. - Publication Year :
- 2019
-
Abstract
- The purpose of this study is to examine the melanocortin-1 receptor (MC1R) targeting and specificity of <superscript>203</superscript> Pb-DOTA-GGNle-CycMSH <subscript>hex</subscript> in melanoma cells and tumors to facilitate its potential therapeutic application when labeled with <superscript>212</superscript> Pb. The MC1R-specific targeting and imaging properties of <superscript>203</superscript> Pb-DOTA-GGNle-CycMSH <subscript>hex</subscript> were determined on B16/F1 and B16/F10 murine melanoma cells and in B16/F1 flank melanoma-, B16/F10 flank melanoma-, and B16/F10 pulmonary metastatic melanoma-bearing C57 mice. <superscript>203</superscript> Pb-DOTA-GGNle-CycMSH <subscript>hex</subscript> displayed MC1R-specific binding on B16/F1 and B16/F10 melanoma cells and tumors. B16/F1 flank melanoma, B16/F10 flank melanoma, and B16/F10 pulmonary metastatic melanoma lesions could be clearly imaged by single photon emission computed tomography (SPECT) using <superscript>203</superscript> Pb-DOTA-GGNle-CycMSH <subscript>hex</subscript> as an imaging probe. The favorable melanoma targeting and imaging properties highlighted the potential of <superscript>203</superscript> Pb-DOTA-GGNle-CycMSH <subscript>hex</subscript> as a MC1R-targeting melanoma imaging probe and warranted the evaluation of <superscript>212</superscript> Pb-DOTA-GGNle-CycMSH <subscript>hex</subscript> for melanoma therapy in future studies.
- Subjects :
- Animals
Cyclization
Lung Neoplasms diagnostic imaging
Lung Neoplasms metabolism
Melanoma, Experimental diagnostic imaging
Melanoma, Experimental metabolism
Mice
Mice, Inbred C57BL
Tissue Distribution
Tomography, Emission-Computed, Single-Photon
Lactams chemistry
Lead Radioisotopes chemistry
Lung Neoplasms secondary
Melanoma, Experimental pathology
Peptide Fragments pharmacokinetics
alpha-MSH metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1543-8392
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 30763112
- Full Text :
- https://doi.org/10.1021/acs.molpharmaceut.9b00025