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Radiation and Its Impact on Local Recurrence in Extremity and Trunk Well-Differentiated Liposarcomas.
- Source :
-
The American surgeon [Am Surg] 2019 Jan 01; Vol. 85 (1), pp. 52-58. - Publication Year :
- 2019
-
Abstract
- Patients with well-differentiated liposarcomas (WDLPS) of the extremity and trunk are treated primarily with surgical resection, with radiation used for a number of anecdotal reasons, including large size and positive margins. In this study, we evaluate the appropriate role for radiation in these tumors. A retrospective chart review of patients with extremity and trunk soft tissue liposarcomas referred to a free-standing cancer center from January 1995 to December 2011 was performed. One hundred eighty-three patients with extremity and trunk soft tissue WDLPS were identified: 61 per cent were female, median age was 60 years (range, 19-84 years) and 2 per cent had a focal area of dedifferentiation, margin status was positive in 57 per cent. Fourteen per cent of patients received radiation. Fifty patients developed recurrent disease; 28 per cent of these received radiation. Median time to recurrence was 18 years (range, 0.7-22 years). Of the 50 patients who recurred, 14 (28%) received radiation. Radiation was associated with decreased second recurrence when administered for recurrent disease ( P = 0.03). On multivariable analysis, tumor size ≤ 10 cm ( P = 0.014) and anatomically difficult area of resection ( P = 0.008) were predictive of increased risk of recurrence. Older age ( P = 0.02), dedifferentiated liposarcomas ( P < 0.001), and difficult area of resection ( P = 0.02) were associated with the administration of radiotherapy. Administration of radiation therapy was not associated with decreased time to recurrence in WDLPS overall; however, it should be considered in patients with recurrent disease.
- Subjects :
- Adult
Aged
Aged, 80 and over
Disease-Free Survival
Female
Humans
Liposarcoma pathology
Liposarcoma surgery
Male
Middle Aged
Retrospective Studies
Soft Tissue Neoplasms pathology
Soft Tissue Neoplasms surgery
Treatment Outcome
Young Adult
Extremities
Liposarcoma radiotherapy
Neoplasm Recurrence, Local epidemiology
Soft Tissue Neoplasms radiotherapy
Torso
Subjects
Details
- Language :
- English
- ISSN :
- 1555-9823
- Volume :
- 85
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The American surgeon
- Publication Type :
- Academic Journal
- Accession number :
- 30760345