Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation.

Authors :: Zhang MM
Liu N
Zhang YL
Rong B
Wang XL
Xu CH
Xie YY
Shen S
Zhu J
Nimer SD
Chen Z
Chen SJ
Roeder RG
Lan F
Wang L
Huang QH
Sun XJ
Source :: Leukemia [Leukemia] 2019 Jul; Vol. 33 (7), pp. 1822-1827. Date of Electronic Publication: 2019 Feb 12.
Publication Year :: 2019

Subjects :: Animals
Basic Helix-Loop-Helix Transcription Factors genetics
Basic Helix-Loop-Helix Transcription Factors metabolism
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
CCAAT-Enhancer-Binding Protein-alpha genetics
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
Core Binding Factor Alpha 2 Subunit genetics
Core Binding Factor Alpha 2 Subunit metabolism
Humans
Inhibitor of Differentiation Protein 1 genetics
Inhibitor of Differentiation Protein 1 metabolism
Leukemia genetics
Leukemia metabolism
Mice
Neoplasm Proteins genetics
Neoplasm Proteins metabolism
Oncogene Proteins, Fusion genetics
Oncogene Proteins, Fusion metabolism
RUNX1 Translocation Partner 1 Protein genetics
RUNX1 Translocation Partner 1 Protein metabolism
T-Cell Acute Lymphocytic Leukemia Protein 1 genetics
T-Cell Acute Lymphocytic Leukemia Protein 1 metabolism
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Basic Helix-Loop-Helix Transcription Factors antagonists & inhibitors
CCAAT-Enhancer-Binding Protein-alpha metabolism
Cell Differentiation
Core Binding Factor Alpha 2 Subunit chemistry
Gene Expression Regulation, Neoplastic
Leukemia pathology
Neoplasm Proteins antagonists & inhibitors
Oncogene Proteins, Fusion chemistry
RUNX1 Translocation Partner 1 Protein chemistry
Translocation, Genetic

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