Back to Search
Start Over
IL-24 contributes to skin inflammation in Para-Phenylenediamine-induced contact hypersensitivity.
- Source :
-
Scientific reports [Sci Rep] 2019 Feb 12; Vol. 9 (1), pp. 1852. Date of Electronic Publication: 2019 Feb 12. - Publication Year :
- 2019
-
Abstract
- Para-Phenylenediamine (PPD) is an aromatic amine used in hair dyes and in temporary black henna tattoos, which is a frequent cause of allergic contact dermatitis (ACD). ACD is a skin inflammatory reaction characterized by modifications such as spongiosis, exocytosis and acanthosis. The aim of this study is to characterize the expression and the role of IL-20-related cytokines, including IL-19, IL-20, IL-22 and IL-24, in ACD. The expression of IL19, IL20, IL22 and IL24 is increased in affected skin from PPD allergic patients compared with uninvolved skin. In addition, the expression of these cytokines positively correlates with clinical symptoms. To assess their role in ACD, we set up a mouse model of PPD-induced allergic contact dermatitis and we showed that, in contrast to Il22-deficient mice, Il22ra1-, Il20rb- and Il24-deficient mice are partially protected against development of PPD-induced contact hypersensitivity. These mice have decreased ear thickening and less acanthosis compared with WT mice after PPD treatment. In addition, the absence of IL-22R, IL-20R2 or IL-24 affects the recruitment of neutrophils into the skin but not the total IgE production. Taken together, these results demonstrate the implication of IL-24 via the IL-20R type II receptor in the inflammatory process of ACD.
- Subjects :
- Adult
Aged
Animals
Biopsy
Coloring Agents
Disease Models, Animal
Humans
Immunoglobulin E metabolism
Inflammation metabolism
Leukocyte Common Antigens metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Middle Aged
Phenylenediamines
Receptors, Interleukin metabolism
Skin metabolism
Interleukin-22
Cytokines metabolism
Dermatitis, Allergic Contact metabolism
Inflammation chemically induced
Interleukins metabolism
Skin drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 30755657
- Full Text :
- https://doi.org/10.1038/s41598-018-38156-4