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Glutathione Metabolism: An Achilles' Heel of ARID1A-Deficient Tumors.
- Source :
-
Cancer cell [Cancer Cell] 2019 Feb 11; Vol. 35 (2), pp. 161-163. - Publication Year :
- 2019
-
Abstract
- In this issue of Cancer Cell, Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This work reveals that synthesis of reduced glutathione is a metabolic dependency of cancers with ARID1A-inactivating mutations.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 35
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 30753819
- Full Text :
- https://doi.org/10.1016/j.ccell.2019.01.017