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Heart failure with preserved ejection fraction, atrial fibrillation, and the role of senile amyloidosis.

Authors :
van den Berg MP
Mulder BA
Klaassen SHC
Maass AH
van Veldhuisen DJ
van der Meer P
Nienhuis HLA
Hazenberg BPC
Rienstra M
Source :
European heart journal [Eur Heart J] 2019 Apr 21; Vol. 40 (16), pp. 1287-1293.
Publication Year :
2019

Abstract

Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are very common conditions, particularly in the elderly. However, the mechanisms underlying the two disorders, including their intricate interaction have not been fully resolved. Here, our aim is to review the evidence on the role of the two types of senile amyloidosis in this connection. Two types of senile amyloidosis can be identified: wild-type transthyretin (TTR)-derived amyloidosis (ATTRwt) and isolated atrial amyloidosis (IAA). ATTRwt is an underlying condition that is being increasingly recognized in patients with HFpEF and often accompanied by AF. IAA is an established cause of AF, adding to the mechanism problem. New diagnostic and therapeutic possibilities have emerged that may facilitate clinical management of (senile) amyloidosis, which in turn may have implications for the management of HFpEF and AF.<br /> (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.)

Details

Language :
English
ISSN :
1522-9645
Volume :
40
Issue :
16
Database :
MEDLINE
Journal :
European heart journal
Publication Type :
Academic Journal
Accession number :
30753432
Full Text :
https://doi.org/10.1093/eurheartj/ehz057