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Protective effect of a topical sunscreen formulation fortified with melatonin against UV-induced photodermatitis: an immunomodulatory effect via NF-κB suppression.
- Source :
-
Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2019 Feb; Vol. 41 (1), pp. 130-139. Date of Electronic Publication: 2019 Feb 11. - Publication Year :
- 2019
-
Abstract
- Objective: Melatonin and pumpkin seed oil, along with US FDA approved UV filters were incorporated into a formulation for enhancement of UV protection by exerting an antioxidant effect. The objective of this study was to assess the protective effect of this formulation against ultraviolet (UV) radiation-induced photo dermatitis in rats, which is an established model to study the aetiopathogenic mechanisms in psoriasis vulgaris, as the former exhibits the same features to those of clinical psoriasis vulgaris in humans. Materials and methods: The animals were segregated into five groups (6/group) and all received their respective formulations dermally prior to chronic UV irradiation for 28 days. The test, placebo, and standard groups; received the test, placebo, and standard formulations respectively; whereas the positive control group received only UV radiation. A normal control group was also maintained. Disease and treatment status were analyzed using various techniques by euthanizing the rats after 28 days. Results: The test formulation was able to ameliorate the UV-induced increase in skin fold, epidermal thickness, and skin edema; inhibit the reduction of hydroxyproline content and incidence of LPO within the skin tissues of exposed animals. The formulation was also able to inhibit the release of proinflammatory cytokines; IFN-γ, IL-1β, IL-6, and TNF-α; and upregulation of NF-κB and COX-2 genes caused by chronic UV exposure. Conclusion: It can be stated that melatonin included in the newly formulated sunscreen was able to inhibit the induction of photodermatitis via immunoregulation of inflammatory cytokines along with NF-κB and COX-2 genes.
- Subjects :
- Animals
Antioxidants metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Combinations
Male
Melatonin administration & dosage
NF-kappa B genetics
Photosensitivity Disorders immunology
Photosensitivity Disorders pathology
Psoriasis etiology
Psoriasis immunology
Psoriasis prevention & control
Rats, Wistar
Skin immunology
Skin pathology
Sunscreening Agents administration & dosage
Melatonin pharmacology
NF-kappa B antagonists & inhibitors
Photosensitivity Disorders prevention & control
Skin drug effects
Sunscreening Agents pharmacology
Ultraviolet Rays
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2513
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Immunopharmacology and immunotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 30741582
- Full Text :
- https://doi.org/10.1080/08923973.2019.1566358