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Quality of life and cost of strategies of two chemotherapy lines in metastatic colorectal cancer: results of the FFCD 2000-05 trial.
- Source :
-
Expert review of pharmacoeconomics & outcomes research [Expert Rev Pharmacoecon Outcomes Res] 2019 Oct; Vol. 19 (5), pp. 601-608. Date of Electronic Publication: 2019 Feb 15. - Publication Year :
- 2019
-
Abstract
- Objectives : This study compared the cost and quality of life (QoL) of 407 advanced colorectal cancer patients, randomly assigned to receive LV5FU2 followed by FOLFOX6 (sequential strategy) or FOLFOX6 followed by FOLFIRI (combination strategy). Methods : Costs were compared from the French health insurance perspective, until the end of the second line of treatment. Consumed resources, collected during the trial, included medicines, hospitalizations, examinations, and transportation. Valuations were made using 2009 and 2016 tariffs. QoL was assessed using the QLQ-C30 questionnaire and clinically significant variations were searched. Results : In 2009, the mean cost per patient was significantly lower for the sequential strategy compared to the combination strategy (18,061€ and 23,119€, p = 0.001). In 2016, the difference was no longer significant (16,876€ and 18,090€, p = 0.41) because oxaliplatin and irinotecan became generics. The QoL analysis (292 patients) showed that there was significantly less improvement of global health status in the sequential strategy than in the combination strategy (29% and 42%; p = 0.02) during first-line therapy. No significant differences were observed for emotional functioning (p = 0.45) and physical functioning (p = 0.07) or during second-line therapy. Conclusion : The choice to treat patients with advanced colorectal cancer using one or the other strategy cannot be based on costs or QoL.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols economics
Camptothecin administration & dosage
Camptothecin analogs & derivatives
Camptothecin economics
Colorectal Neoplasms economics
Colorectal Neoplasms pathology
Drug Costs
Female
Fluorouracil administration & dosage
Fluorouracil economics
France
Health Status
Humans
Leucovorin administration & dosage
Leucovorin economics
Male
Middle Aged
Neoplasm Metastasis
Organoplatinum Compounds administration & dosage
Organoplatinum Compounds economics
Prospective Studies
Surveys and Questionnaires
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Colorectal Neoplasms drug therapy
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8379
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Expert review of pharmacoeconomics & outcomes research
- Publication Type :
- Academic Journal
- Accession number :
- 30739558
- Full Text :
- https://doi.org/10.1080/14737167.2019.1580573