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Pemphigus and mucous membrane pemphigoid: An update from diagnosis to therapy.
- Source :
-
Autoimmunity reviews [Autoimmun Rev] 2019 Apr; Vol. 18 (4), pp. 349-358. Date of Electronic Publication: 2019 Feb 07. - Publication Year :
- 2019
-
Abstract
- Pemphigus diseases (PDs) and mucous membrane pemphigoid (MMP) are a group of immune-mediated mucocutaneous disorders clinically characterized by the formation of blisters, erosions and ulcers. The skin and mucous membranes are predominantly affected, with the oropharyngeal mucosa as the initially involved site. Ocular involvement is also a frequent feature of these diseases. Because of the considerable overlap in their clinical presentations, the diagnosis of PDs vs. MMP can be challenging. A recognition of their specific immunological and histopathologic features is crucial in the differential diagnosis. Treatment modalities include systemically administered corticosteroids, steroid-sparing immunosuppressive agents, and biologic therapies (rituximab, intravenous immunoglobulins, and anti-tumor necrosis factor agents). Topical, oral, conjunctival, or intralesional corticosteroids as well as anti-inflammatory drugs and antibiotics are prescribed as needed.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adrenal Cortex Hormones therapeutic use
Diagnosis, Differential
Humans
Immunoglobulins, Intravenous therapeutic use
Immunosuppressive Agents therapeutic use
Pemphigoid, Bullous diagnosis
Pemphigoid, Bullous therapy
Pemphigus immunology
Rituximab therapeutic use
Pemphigoid, Benign Mucous Membrane diagnosis
Pemphigoid, Benign Mucous Membrane therapy
Pemphigus diagnosis
Pemphigus therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-0183
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Autoimmunity reviews
- Publication Type :
- Academic Journal
- Accession number :
- 30738958
- Full Text :
- https://doi.org/10.1016/j.autrev.2019.02.005