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Comparison of neointimal coverage between durable-polymer everolimus-eluting stents and bioresorbable-polymer everolimus-eluting stents 1 year after implantation using high-resolution coronary angioscopy.
- Source :
-
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions [Catheter Cardiovasc Interv] 2019 Aug 01; Vol. 94 (2), pp. 204-209. Date of Electronic Publication: 2019 Feb 09. - Publication Year :
- 2019
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Abstract
- Objectives: We aimed to compare the coronary angioscopic appearance of neointimal coverage (NIC) over durable-polymer everolimus-eluting stents (XIENCE-EES) and bioresorbable-polymer everolimus-eluting stents (SYNERGY-EES) 1 year after implantation.<br />Background: XIENCE-EES and SYNERGY-EES have been developed to prevent delayed arterial healing associated with first generation drug-eluting stents. However, the process of arterial healing after XIENCE-EES and SYNERGY-EES implantation has not been clarified.<br />Methods: Patients who underwent implantation of XIENCE-EES (n = 20) or SYNERGY-EES (n = 20) were enrolled in this study. Coronary angiography and coronary angioscopy were performed 12 ± 1 months after stent implantation. The NIC over the stent was classified into four grades: grade 0, stent struts fully exposed; grade 1, stent struts bulging into the lumen and, still visible; grade 2, stent struts embedded in neointima but still visible; and grade 3, stent struts fully embedded and invisible. Stents exhibiting more than one NIC grade was defined as heterogeneous. Moreover, presence of thrombi was investigated.<br />Results: The distribution of dominant NIC grade (XIENCE-EES: grade 0, 0%; grade 1, 25%; grade 2, 50%; grade 3, 25%; SYNERGY-EES: grade 0, 0%; grade 1, 5%; grade 2, 15%; grade 3, 80%; P = 0.002) and NIC heterogeneity was significantly different (P = 0.004). Thrombi were more frequent in XIENCE-EES than in SYNERGY-EES (40 versus 10%, respectively; P = 0.03).<br />Conclusion: Compared with XIENCE-EES, SYNERGY-EES were well covered by neointima and accompanied by fewer thrombi. These findings implied arterial healing of SYNERGY-EES was better than that of XIENCE-EES.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Aged
Aged, 80 and over
Cardiovascular Agents adverse effects
Coronary Angiography
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease pathology
Coronary Thrombosis etiology
Coronary Thrombosis pathology
Coronary Vessels diagnostic imaging
Everolimus adverse effects
Female
Humans
Male
Middle Aged
Percutaneous Coronary Intervention adverse effects
Predictive Value of Tests
Prosthesis Design
Time Factors
Treatment Outcome
Wound Healing
Angioscopy
Cardiovascular Agents administration & dosage
Coated Materials, Biocompatible
Coronary Artery Disease therapy
Coronary Vessels pathology
Drug-Eluting Stents
Everolimus administration & dosage
Neointima
Percutaneous Coronary Intervention instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1522-726X
- Volume :
- 94
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
- Publication Type :
- Academic Journal
- Accession number :
- 30737973
- Full Text :
- https://doi.org/10.1002/ccd.28095