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The siRNAsome: A Cation-Free and Versatile Nanostructure for siRNA and Drug Co-delivery.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Apr 01; Vol. 58 (15), pp. 4938-4942. Date of Electronic Publication: 2019 Mar 03. - Publication Year :
- 2019
-
Abstract
- Nanoparticles show great potential for drug delivery. However, suitable nanostructures capable of loading a range of drugs together with the co-delivery of siRNAs, which avoid the problem of cation-associated cytotoxicity, are lacking. Herein, we report an small interfering RNA (siRNA)-based vesicle (siRNAsome), which consists of a hydrophilic siRNA shell, a thermal- and intracellular-reduction-sensitive hydrophobic median layer, and an empty aqueous interior that meets this need. The siRNAsome can serve as a versatile nanostructure to load drug agents with divergent chemical properties, therapeutic proteins as well as co-delivering immobilized siRNAs without transfection agents. Importantly, the inherent thermal/reduction-responsiveness enables controlled drug loading and release. When siRNAsomes are loaded with the hydrophilic drug doxorubicin hydrochloride and anti-P-glycoprotein siRNA, synergistic therapeutic activity is achieved in multidrug resistant cancer cells and a tumor model.<br /> (© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)
- Subjects :
- Antibiotics, Antineoplastic chemistry
Breast Neoplasms metabolism
Breast Neoplasms pathology
Cell Proliferation drug effects
Cell Survival drug effects
Doxorubicin chemistry
Drug Resistance, Multiple drug effects
Drug Screening Assays, Antitumor
Humans
Hydrophobic and Hydrophilic Interactions
MCF-7 Cells
Antibiotics, Antineoplastic pharmacology
Breast Neoplasms drug therapy
Doxorubicin pharmacology
Drug Delivery Systems
Nanostructures chemistry
RNA, Small Interfering chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 58
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 30737876
- Full Text :
- https://doi.org/10.1002/anie.201814289