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Non-invasive Assessment of Dorsiflexor Muscle Function in Mice.
- Source :
-
Journal of visualized experiments : JoVE [J Vis Exp] 2019 Jan 17 (143). Date of Electronic Publication: 2019 Jan 17. - Publication Year :
- 2019
-
Abstract
- Assessment of skeletal muscle contractile function is an important measurement for both clinical and research purposes. Numerous conditions can negatively affect skeletal muscle. This can result in a loss of muscle mass (atrophy) and/or loss of muscle quality (reduced force per unit of muscle mass), both of which are prevalent in chronic disease, muscle-specific disease, immobilization, and aging (sarcopenia). Skeletal muscle function in animals can be evaluated by a range of different tests. All tests have limitations related to the physiological testing environment, and the selection of a specific test often depends on the nature of the experiments. Here, we describe an in vivo, non-invasive technique involving a helpful and easy assessment of force frequency-curve (FFC) in mice that can be performed on the same animal over time. This permits monitoring of disease progression and/or efficacy of a potential therapeutic treatment.
Details
- Language :
- English
- ISSN :
- 1940-087X
- Issue :
- 143
- Database :
- MEDLINE
- Journal :
- Journal of visualized experiments : JoVE
- Publication Type :
- Academic Journal
- Accession number :
- 30735157
- Full Text :
- https://doi.org/10.3791/58696