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Alteration in gene expression profile of thymomas with or without myasthenia gravis linked with the nuclear factor-kappaB/autoimmune regulator pathway to myasthenia gravis pathogenesis.
- Source :
-
Thoracic cancer [Thorac Cancer] 2019 Mar; Vol. 10 (3), pp. 564-570. Date of Electronic Publication: 2019 Feb 07. - Publication Year :
- 2019
-
Abstract
- Background: To investigate the gene expression profile of a set of candidate genes for a better understanding of the molecular mechanism underlying the pathogenesis of thymoma with or without myasthenia gravis.<br />Methods: Thymoma patients and thymoma patients with myasthenia gravis were analyzed using microarray profiling to identify significant changes in gene expression of autoimmune regulator pathway genes including AIRE, IL-7R, CHRNA3, SYMD1, THRA, and CAV3.<br />Results: Across all of our samples, we found that 1484 mRNAs were upregulated and 770 were downregulated in thymoma patients compared with thymoma with myasthenia gravis patients. Gene ontology and pathway analysis revealed that a large number of genes participated in cellular functions for humoral immune response, sequence-specific DNA binding RNA polymerase II transcription factor activity, positive regulation of gene expression, regulation of neuron projection development, extracellular ligand-gated ion channel activity, positive regulation of striated muscle cell differentiation, and regulation of nuclear factor-kappaB import into the nucleus.<br />Conclusion: Our results revealed genetic differences between thymomas and myasthenia gravis, and identified the key candidate genes/pathways for molecular mechanism.<br /> (© 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adult
Autoimmune Diseases complications
Autoimmune Diseases genetics
Autoimmune Diseases pathology
Caveolin 3 genetics
Female
Gene Expression Regulation, Neoplastic genetics
Humans
Male
Microarray Analysis
Middle Aged
Myasthenia Gravis complications
Myasthenia Gravis pathology
NF-kappa B genetics
Receptors, Interleukin-7 genetics
Receptors, Nicotinic genetics
Thymoma complications
Thymoma pathology
Thyroid Hormone Receptors alpha genetics
Transcription Factors genetics
AIRE Protein
Myasthenia Gravis genetics
Neoplasm Proteins genetics
Thymoma genetics
Transcriptome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1759-7714
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Thoracic cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30734484
- Full Text :
- https://doi.org/10.1111/1759-7714.12980