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GDF11 is increased in patients with aplastic anemia.
- Source :
-
Hematology (Amsterdam, Netherlands) [Hematology] 2019 Dec; Vol. 24 (1), pp. 331-336. - Publication Year :
- 2019
-
Abstract
- Object: To explore the critical role of growth differentiation factor 11 (GDF11) in the pathobiology of aplastic anemia (AA).<br />Methods: We have examined the serum GDF11 levels for 79 AA patients and 30 healthy controls. A total of 79 AA patients, which included 29 new diagnosed (untreated) cases, 14 cases with no response, 21 partial remission (PR) cases and 15 complete remission (CR) cases after immunosuppressive therapy (IST). GDF11 serum levels were assessed by an enzyme-linked immunosorbent assay. GDF11 mRNA expression in peripheral blood mononuclear (PBMNC) was detected through real time polymerase chain reaction. The correlation between GDF11 expression and erythropoietic function was evaluated.<br />Results: The serum GDF11 levels in untreated AA patients were higher than that of the control group. The serum GDF11 levels of PR patients or CR patients after IST was decreased, compared with untreated patients, but did not recover back to the normal levels. GDF11 levels had a negative correlation with hemoglobin (Hb) levels and reticulocyte counts in AA patients. GDF11 levels did not correlate with age, sex and severity of in AA patients.<br />Conclusion: Serum GDF11 levels were increased and negatively correlated with Hb levels and reticulocyte counts in AA patients. This suggests an impaired GDF11 response contributing to anemia in AA patients.
- Subjects :
- Adolescent
Adult
Aged
Anemia, Aplastic pathology
Anemia, Aplastic therapy
Child
Female
Humans
Immunosuppression Therapy
Leukocytes, Mononuclear pathology
Male
Middle Aged
Reticulocyte Count
Anemia, Aplastic blood
Bone Morphogenetic Proteins blood
Gene Expression Regulation
Growth Differentiation Factors blood
Leukocytes, Mononuclear metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1607-8454
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hematology (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 30727851
- Full Text :
- https://doi.org/10.1080/16078454.2019.1574386