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Sex-specific associations between insulin resistance and bone parameters in overweight and obese older adults.
- Source :
-
Clinical endocrinology [Clin Endocrinol (Oxf)] 2019 May; Vol. 90 (5), pp. 680-689. Date of Electronic Publication: 2019 Mar 01. - Publication Year :
- 2019
-
Abstract
- Objectives: To determine sex-specific associations between insulin resistance and bone parameters measured by peripheral quantitative computed tomography in overweight and obese community-dwelling older adults.<br />Study Design: Cross-sectional study of 79 community-dwelling overweight and obese adults (mean ± SD age 62.8 ± 7.9 years; body mass index 32.3 ± 6.1 kg/m <superscript>2</superscript> ; 58% women).<br />Main Outcome Measures: Peripheral quantitative computed tomography assessed distal radius and tibia trabecular volumetric bone mineral density (vBMD) and proximal radius and tibia cortical vBMD, periosteal circumference, endosteal circumference and stress-strain index. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score was calculated from fasting glucose and insulin values. Lean mass was assessed using dual-energy X-ray absorptiometry. Total minutes of moderate and vigorous physical activity (MVPA) were calculated using the Active Australia Survey.<br />Results: Men and women in this cohort had no significant differences in fasting glucose and insulin concentrations, HOMA-IR values and diabetes prevalence (all P > 0.05). In women, HOMA-IR was positively correlated with proximal radius periosteal and endosteal circumference (r = 0.331; P = 0.034 and r = 0.325; P = 0.038, respectively). These associations became nonsignificant in multivariable regression analyses; however, HOMA-IR was negatively associated with proximal radius cortical vBMD (B = -4.79; 95% CI -8.66, -0.92) after adjusting for age, lean mass and MVPA. All associations between HOMA-IR and bone parameters became nonsignificant in a sensitivity analysis excluding individuals with diabetes, or self-reported use of glucose-lowering medications. There were no associations between HOMA-IR and bone parameters in men.<br />Conclusions: Homeostatic Model Assessment of Insulin Resistance was negatively associated with radial cortical vBMD in overweight and obese older women, but not in men. Further studies are needed to clarify sex-specific associations between insulin resistance and bone health in overweight and obese older adults.<br /> (© 2019 John Wiley & Sons Ltd.)
- Subjects :
- Absorptiometry, Photon
Aged
Female
Humans
Male
Middle Aged
Obesity diagnostic imaging
Obesity epidemiology
Obesity metabolism
Tomography, X-Ray Computed
Victoria epidemiology
Bone Density
Insulin Resistance
Overweight diagnostic imaging
Overweight epidemiology
Overweight metabolism
Sex Characteristics
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2265
- Volume :
- 90
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 30724369
- Full Text :
- https://doi.org/10.1111/cen.13947