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Effects of 2-methylthio ATP on insulin secretion in the dog in vivo.

Authors :
Ribes G
Bertrand G
Petit P
Loubatières-Mariani MM
Source :
European journal of pharmacology [Eur J Pharmacol] 1988 Oct 11; Vol. 155 (1-2), pp. 171-4.
Publication Year :
1988

Abstract

The effects of 2-methylthio ATP, an ATP analogue that is more specific for the P2Y receptor, were investigated on insulin secretion in the anesthetized dog in vivo. 2-Methylthio ATP was infused directly into the pancreaticoduodenal artery for 15 min. The infusion was performed so as to obtain a pancreaticoduodenal artery blood level of about 15 microM. 2-Methylthio ATP induced an immediate and significant stimulation of insulin secretion measured from the pancreaticoduodenal vein by means of a T-shaped catheter. After the infusion was stopped, the secretion of insulin progressively decreased and at 30 min was close to basal values. The stimulation of insulin secretion induced a transient but significant reduction of peripheral venous blood glucose levels.

Details

Language :
English
ISSN :
0014-2999
Volume :
155
Issue :
1-2
Database :
MEDLINE
Journal :
European journal of pharmacology
Publication Type :
Academic Journal
Accession number :
3072210
Full Text :
https://doi.org/10.1016/0014-2999(88)90418-9