G4Hunter web application: a web server for G-quadruplex prediction.

Authors :: Brázda V
Kolomazník J
Lýsek J
Bartas M
Fojta M
Šťastný J
Mergny JL
Source :: Bioinformatics (Oxford, England) [Bioinformatics] 2019 Sep 15; Vol. 35 (18), pp. 3493-3495.
Publication Year :: 2019
Abstract: Motivation: Expanding research highlights the importance of guanine quadruplex structures. Therefore, easy-accessible tools for quadruplex analyses in DNA and RNA molecules are important for the scientific community.<br />Results: We developed a web version of the G4Hunter application. This new web-based server is a platform-independent and user-friendly application for quadruplex analyses. It allows retrieval of gene/nucleotide sequence entries from NCBI databases and provides complete characterization of localization and quadruplex propensity of quadruplex-forming sequences. The G4Hunter web application includes an interactive graphical data representation with many useful options including visualization, sorting, data storage and export.<br />Availability and Implementation: G4Hunter web application can be accessed at: http://bioinformatics.ibp.cz.<br />Supplementary Information: Supplementary data are available at Bioinformatics online.<br /> (© The Author(s) 2019. Published by Oxford University Press.)