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Protein biomarkers in serum and urine for determining presence or absence of hip dysplasia in a canine model.
- Source :
-
Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2019 Apr; Vol. 37 (4), pp. 916-920. Date of Electronic Publication: 2019 Feb 28. - Publication Year :
- 2019
-
Abstract
- This study compares serum and urine concentrations of relevant protein biomarkers among adult dogs with or without radiographic canine hip dysplasia (CHD). Adult (≥2 years of age), client-owned dogs (n = 74) radiographically categorized as having at least "good" hips (n = 49) or having "mild," "moderate," or "severe" hip dysplasia (n = 25) by the Orthopedic Foundation for Animals (OFA). Urine and serum samples were obtained from each dog at a single time-point and processed and analyzed for relevant protein biomarkers. Urinary concentrations of CTX-II (p < 0.001) and TIMP-1 (p = 0.002) were significantly lower in dogs with CHD compared to dogs with no CHD. ROC curve analyses were successful in establishing a panel of four biomarkers (urinary CTX-I and II, serum MMP-9, and serum PIICP) with high discriminatory capability for the presence or absence of hip dysplasia in adult dogs (AUC = 0.89). Urine and serum biomarkers can distinguish adult dogs with radiographic CHD from those with no CHD with a sensitivity of 0.95 and specificity of 0.77 using ROC analysis with AUC 0.89. Clinical Significance: This finding suggests that this simple, minimally invasive diagnostic technique has potential for discriminating dysplastic dogs from dogs with normal hips, with possible translational application to humans based on similar etiopathogenesis. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 9999:1-5, 2019.<br /> (© 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.)
- Subjects :
- Animals
Biomarkers blood
Biomarkers urine
Calcium-Binding Proteins blood
Collagen Type I urine
Collagen Type II blood
Dogs
Female
Hip Dysplasia, Canine blood
Hip Dysplasia, Canine diagnostic imaging
Male
Matrix Metalloproteinase 9 blood
Radiography
Collagen Type II urine
Hip Dysplasia, Canine urine
Tissue Inhibitor of Metalloproteinase-1 urine
Subjects
Details
- Language :
- English
- ISSN :
- 1554-527X
- Volume :
- 37
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 30720210
- Full Text :
- https://doi.org/10.1002/jor.24242