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Diuretic Effects of Sodium Glucose Cotransporter 2 Inhibitors and Their Influence on the Renin-Angiotensin System.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2019 Feb 01; Vol. 20 (3). Date of Electronic Publication: 2019 Feb 01. - Publication Year :
- 2019
-
Abstract
- The renin-angiotensin system (RAS) plays an important role in regulating body fluids and blood pressure. However, inappropriate activation of the RAS contributes to the pathogenesis of cardiovascular and renal diseases. Recently, sodium glucose cotransporter 2 (SGLT2) inhibitors have been used as anti-diabetic agents. SGLT2 inhibitors induce glycosuria and improve hyperglycemia by inhibiting urinary reabsorption of glucose. However, in the early stages of treatment, these inhibitors frequently cause polyuria and natriuresis, which potentially activate the RAS. Nevertheless, the effects of SGLT2 inhibitors on RAS activity are not straightforward. Available data indicate that treatment with SGLT2 inhibitors transiently activates the systemic RAS in type 2 diabetic patients, but not the intrarenal RAS. In this review article, we summarize current evidence of the diuretic effects of SGLT2 inhibitors and their influence on RAS activity.
- Subjects :
- Blood Pressure drug effects
Diabetes Mellitus, Type 2 genetics
Diabetes Mellitus, Type 2 metabolism
Diabetes Mellitus, Type 2 physiopathology
Diuretics adverse effects
Gene Expression drug effects
Glucose metabolism
Glycosuria drug therapy
Glycosuria genetics
Glycosuria metabolism
Glycosuria physiopathology
Humans
Hyperglycemia drug therapy
Hyperglycemia genetics
Hyperglycemia metabolism
Hyperglycemia physiopathology
Hypertension drug therapy
Hypertension genetics
Hypertension metabolism
Hypertension physiopathology
Hypoglycemic Agents adverse effects
Natriuresis drug effects
Polyuria chemically induced
Polyuria metabolism
Polyuria physiopathology
Sodium-Glucose Transporter 2 metabolism
Sodium-Glucose Transporter 2 Inhibitors adverse effects
Diabetes Mellitus, Type 2 drug therapy
Diuretics administration & dosage
Hypoglycemic Agents administration & dosage
Renin-Angiotensin System drug effects
Sodium-Glucose Transporter 2 genetics
Sodium-Glucose Transporter 2 Inhibitors administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30717173
- Full Text :
- https://doi.org/10.3390/ijms20030629