Back to Search
Start Over
Reduced Serum and Cerebrospinal Fluid Levels of Autotaxin in Major Depressive Disorder.
- Source :
-
The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2019 Apr 01; Vol. 22 (4), pp. 261-269. - Publication Year :
- 2019
-
Abstract
- Background: The autotaxin/lysophosphatidic acid axis is involved in diverse biological processes including neurodevelopment, inflammation, and immunological functioning. The lysophosphatidic acid 1 receptor has been implicated in the pathophysiology of major depressive disorder and in the mechanism of action of antidepressants. However, it is unclear whether central or peripheral autotaxin levels are altered in patients with major depressive disorder.<br />Methods: Serum autotaxin levels were measured by an enzyme-linked immunosorbent assay in 37 patients with major depressive disorder diagnosed using DSM-IV-TR who underwent electroconvulsive therapy and were compared with those of 47 nondepressed controls matched for age and sex between January 2011 and December 2015. Patient serum levels of autotaxin before and after electroconvulsive therapy were also compared. In a separate sample set, cerebrospinal fluid autotaxin levels were compared between 26 patients with major depressive disorder and 27 nondepressed controls between December 2010 and December 2015. A potential association was examined between autotaxin levels and clinical symptoms assessed with the Hamilton Depression Rating Scale.<br />Results: Before electroconvulsive therapy, both serum and cerebrospinal fluidautotaxin levels were significantly lower in major depressive disorder patients than in controls (serum: P = .001, cerebrospinal fluid: P = .038). A significantly negative correlation between serum, but not cerebrospinal fluid, autotaxin levels and depressive symptoms was observed (P = .032). After electroconvulsive therapy, a parallel increase in serum autotaxin levels and depressive symptoms improvement was observed (P = .005).<br />Conclusion: The current results suggest that serum autotaxin levels are reduced in a state-dependent manner. The reduction of cerebrospinal fluidautotaxin levels suggests a dysfunction in the autotaxin/lysophosphatidic acid axis in the brains of patients with major depressive disorder.<br /> (© The Author(s) 2019. Published by Oxford University Press on behalf of CINP.)
- Subjects :
- Adult
Aged
Electroconvulsive Therapy
Female
Humans
Lysophospholipids metabolism
Male
Middle Aged
Depressive Disorder, Major blood
Depressive Disorder, Major cerebrospinal fluid
Depressive Disorder, Major physiopathology
Depressive Disorder, Major therapy
Phosphoric Diester Hydrolases blood
Phosphoric Diester Hydrolases cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1469-5111
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The international journal of neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 30715387
- Full Text :
- https://doi.org/10.1093/ijnp/pyz005