Back to Search Start Over

Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.

Authors :
Chen H
Chen G
Li G
Zhang S
Chen H
Chen Y
Duggan D
Hu Z
Chen J
Zhao Y
Zhao Y
Huang H
Zheng SL
Trent JM
Yu L
Jiang D
Mo Z
Wang H
Mou Y
Jiang T
Mao Y
Xu J
Lu D
Source :
International journal of cancer [Int J Cancer] 2019 Nov 01; Vol. 145 (9), pp. 2372-2382. Date of Electronic Publication: 2019 Mar 18.
Publication Year :
2019

Abstract

Glioma is the most common malignant primary brain tumors with poor prognosis. Genome wide association studies (GWAS) of glioma in populations with Western European ancestry were completed in the US and UK. However, our previous results strongly suggest the genetic heterogeneity could be important in glioma risk. To systematically investigate glioma risk-associated variants in Chinese population, we performed a multistage GWAS of glioma in the Han Chinese population, with a total of 3,097 glioma cases and 4,362 controls. In addition to confirming two associations reported in other ancestry groups, this study identified one new risk-associated locus for glioma on chromosome 12p11.23 (rs10842893, p <subscript>meta</subscript> = 2.33x10-12, STK38L) as well as a promising association at 15q15-21.1 (rs4774756, p <subscript>meta</subscript> = 6.12x10-8, RAB27A) in 3,097 glioma cases and 4,362 controls. Our findings demonstrate two novel association between the glioma risk region marked by variant rs10842893 and rs4774756) and glioma risk. These findings may advance the understanding of genetic susceptibility to glioma.<br /> (© 2019 UICC.)

Details

Language :
English
ISSN :
1097-0215
Volume :
145
Issue :
9
Database :
MEDLINE
Journal :
International journal of cancer
Publication Type :
Academic Journal
Accession number :
30714141
Full Text :
https://doi.org/10.1002/ijc.32179