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Brucella canis induces canine CD4 + T cells multi-cytokine Th1/Th17 production via dendritic cell activation.
- Source :
-
Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 2019 Feb; Vol. 62, pp. 68-75. Date of Electronic Publication: 2018 Nov 30. - Publication Year :
- 2019
-
Abstract
- Brucella canis is a small intracellular Gram-negative bacterium that frequently leads to chronic infections highly resistant to antibiotic therapy in dogs. Also, it causes mild human brucellosis compared to other zoonotic Brucella spp. Herein we characterize the cellular immune response elicited by B. canis by analysing human and canine CD4 <superscript>+</superscript> T cells after stimulation with autologous monocyte-derived dendritic cells (MoDCs). Human and canine B. canis-primed MoDCs stimulated autologous CD4 <superscript>+</superscript> T cells; however, a Th1 response was triggered by human MoDCs, whereas canine MoDCs induced Th1/Th17 responses, with increased CD4 <superscript>+</superscript> T cells producing IFN-γ and IL-17A simultaneously. Each pattern of cellular response may contribute to host susceptibility, helping to understand the differences in B. canis virulence between these two hosts. In addition, other aspects of canine immunology are unveiled by highlighting the participation of IL-17A-producing canine MoDCs and CD4 <superscript>+</superscript> T cells producing IFN-γ and IL-17A.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Biomarkers
Brucellosis veterinary
Cell Communication immunology
Dendritic Cells metabolism
Dog Diseases immunology
Dog Diseases metabolism
Dog Diseases microbiology
Dogs
Humans
Immunophenotyping
Lymphocyte Activation
Brucella canis immunology
CD4-Positive T-Lymphocytes physiology
Cytokines biosynthesis
Dendritic Cells immunology
Th1 Cells physiology
Th17 Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1667
- Volume :
- 62
- Database :
- MEDLINE
- Journal :
- Comparative immunology, microbiology and infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 30711049
- Full Text :
- https://doi.org/10.1016/j.cimid.2018.11.017