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Clinical and laboratory characterizations of hepatic capillariasis.
- Source :
-
Acta tropica [Acta Trop] 2019 May; Vol. 193, pp. 206-210. Date of Electronic Publication: 2019 Jan 30. - Publication Year :
- 2019
-
Abstract
- Hepatic capillariasis is a rare and neglected parasitic disease caused by infection with Capillaria hepatica in human liver. The disease is not well described and the information for the disease's clinical manifestation, laboratory findings and disease management strategy is not well reported. The limited information for this neglected infection often results in the delay of diagnosis or misdiagnosed to other diseases, therefore the real prevalence or severity of the infection may be underestimated. More case report with systemic analysis and features summary of this disease is needed to better understand the serious zoonotic disease. This study included systemic analysis of 16 patients infected with hepatic capillariasis in China between 2011-2017, including clinical manifestations, laboratory/radiative image findings and treatment results. Clinical manifestation included sustained fever (56.25%), respiratory disorder (37.5%), abdominal pain (37.5%), diarrhea (25%), leukocytosis (93.75%) and eosinophilia (100%). No egg was detected in feces of all patients. Over 60% patients showed elevated level of hepatic enzymes and proteins related to liver fibrosis in sera. Ultrasound and MRI examinations displayed scattered parasitic granuloma leisure in affected liver. Liver biopsy revealed parasite eggs, necrotized parasitic granulomas and septal fibrosis. Treatment with albendazole combined with corticoids for several treatment courses cured all patients with capillariasis. The difficulty of diagnosis, apparent damage of liver functions and potential fibrosis make the disease's prevalence and severity underestimated.<br /> (Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Abdominal Pain parasitology
Adolescent
Adrenal Cortex Hormones therapeutic use
Adult
Alanine Transaminase blood
Albendazole therapeutic use
Animals
Anthelmintics therapeutic use
Aspartate Aminotransferases blood
Child
Child, Preschool
Diarrhea parasitology
Enoplida Infections blood
Enoplida Infections complications
Eosinophilia parasitology
Female
Fever parasitology
Humans
Infant
Leukocytosis parasitology
Liver Cirrhosis blood
Liver Cirrhosis diagnostic imaging
Liver Cirrhosis parasitology
Liver Diseases, Parasitic blood
Liver Diseases, Parasitic complications
Male
Middle Aged
Respiratory Tract Diseases parasitology
Young Adult
Capillaria
Enoplida Infections diagnosis
Enoplida Infections drug therapy
Liver Diseases, Parasitic diagnosis
Liver Diseases, Parasitic drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6254
- Volume :
- 193
- Database :
- MEDLINE
- Journal :
- Acta tropica
- Publication Type :
- Academic Journal
- Accession number :
- 30710532
- Full Text :
- https://doi.org/10.1016/j.actatropica.2019.01.023