Back to Search
Start Over
Intraoperative macroscopic tumour consistency is associated with overall survival after cytoreductive surgery and intraperitoneal chemotherapy for appendiceal adenocarcinoma with peritoneal metastases: A retrospective observational study.
- Source :
-
American journal of surgery [Am J Surg] 2019 Apr; Vol. 217 (4), pp. 704-712. Date of Electronic Publication: 2018 Dec 31. - Publication Year :
- 2019
-
Abstract
- Background: This study examines the impact of intraoperative macroscopic tumour consistency on short-term and long-term outcomes after cytoreductive surgery (CRS) with intraperitoneal chemotherapy (IPC) for appendiceal adenocarcinoma with peritoneal metastases.<br />Methods: Macroscopic intraoperative tumour consistency was classified in three groups as soft (jelly-like geltatinous tumours), hard (hard tumour nodules without gelatinous features) and intermediate (both soft and hard features). In-hospital mortality, major morbidity, intensive care unit (ICU), high dependency unit (HDU) and total hospital stay, disease-free survival (DFS) and overall survival (OS) were compared.<br />Results: The three groups had similar perioperative short-term outcomes. Patients with soft, intermediate and hard tumours revealed differences in OS (p < 0.001) and DFS (p = 0.03). Multivariable analysis revealed a shorter OS for patients with hard versus soft tumours (HR for hard tumours = 4.43, 95%CI 2.19-9.00).<br />Conclusions: Intraoperative macroscopic tumour consistency may be used as a prognostic marker for survival in patients with appendiceal adenocarcinoma with peritoneal metastases.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Adenocarcinoma drug therapy
Appendiceal Neoplasms drug therapy
Chemotherapy, Cancer, Regional Perfusion
Combined Modality Therapy
Female
Humans
Male
Middle Aged
Postoperative Complications
Prognosis
Retrospective Studies
Survival Rate
Adenocarcinoma pathology
Adenocarcinoma surgery
Appendiceal Neoplasms pathology
Appendiceal Neoplasms surgery
Cytoreduction Surgical Procedures
Peritoneal Neoplasms secondary
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1883
- Volume :
- 217
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 30704669
- Full Text :
- https://doi.org/10.1016/j.amjsurg.2018.12.037