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Endogenous IL-17A mediated neutrophil infiltration by promoting chemokines expression during chlamydial lung infection.
- Source :
-
Microbial pathogenesis [Microb Pathog] 2019 Apr; Vol. 129, pp. 106-111. Date of Electronic Publication: 2019 Jan 28. - Publication Year :
- 2019
-
Abstract
- Chlamydia is an obligate intracellular bacteria, which can infect cervix, urethra, conjunctiva, joints, lungs and so on. Neutrophils are important in host protection against microbial invasion during the early phase of infection. Here, to investigate the mechanism of IL-17A in recruiting neutrophils during Chlamydia muridarum (Cm) lung infection, we introduced IL-17A antibodies and IL-17 <superscript>-/-</superscript> mice to confirm the effect of IL-17A on influencing neutrophil attractants expressions. From the analysis of the data, we found that showed that Cm infection could upregulate the expression of neutrophil-related chemokines such as KC, MIP-2 and IL-6, as well as adhesion molecules including ICAM-1 and VCAM-1. With blocking endogenous IL-17A, the upregulated MIP-2 and IL-6 were decreased, which induced less neutrophil recruitment in lung. Comparing to WT mice, IL-17 <superscript>-/-</superscript> mice showed decreased infiltration of neutrophils in lung during the early phase of Cm infection, which were accordant with decreased chemokines, such as KC, MIP-2 and IL-6 expression. Whereas, the expression of adhesion molecules including ICAM and VCAM-1 in lungs were significantly increased in IL-17 <superscript>-/-</superscript> mice comparing to WT mice during Cm lung infection. The results demonstrated that IL-17A influenced neutrophil infiltration by affecting expression of chemokines and adhesion molecules during the early phase of chlamydial lung infection.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Chlamydia Infections immunology
Chlamydia muridarum immunology
Disease Models, Animal
Interleukin-17 antagonists & inhibitors
Interleukin-17 deficiency
Lung pathology
Mice, Inbred C57BL
Mice, Knockout
Pneumonia, Bacterial immunology
Chemokines metabolism
Chlamydia Infections pathology
Chlamydia muridarum pathogenicity
Interleukin-17 metabolism
Neutrophil Infiltration drug effects
Pneumonia, Bacterial pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-1208
- Volume :
- 129
- Database :
- MEDLINE
- Journal :
- Microbial pathogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 30703475
- Full Text :
- https://doi.org/10.1016/j.micpath.2019.01.039