A paradigm towards the antimalarial quest: in silico identification and biological evaluation of novel inhibitors targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Authors :: Sharma D
Dada R
Tejavath KK
Rai P
Soni R
Yaragorla S
Bhatt TK
Source :: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2020 Jan; Vol. 38 (1), pp. 295-301. Date of Electronic Publication: 2019 Feb 10.
Publication Year :: 2020

Subjects :: Amino Acids
Binding Sites
Drug Discovery
Drug Evaluation, Preclinical
Humans
Hydrogen Bonding
Protein Binding
Structure-Activity Relationship
Aldose-Ketose Isomerases antagonists & inhibitors
Aldose-Ketose Isomerases chemistry
Antimalarials chemistry
Antimalarials pharmacology
Models, Molecular
Plasmodium drug effects
Plasmodium enzymology

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