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Dental and craniofacial alterations in long-term survivors of childhood head and neck rhabdomyosarcoma.

Authors :
Mattos VD
Ferman S
Magalhães DMA
Antunes HS
Lourenço SQC
Source :
Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2019 Apr; Vol. 127 (4), pp. 272-281. Date of Electronic Publication: 2018 Dec 21.
Publication Year :
2019

Abstract

Objective: Rhabdomyosarcoma (RMS) represents the most common soft tissue sarcoma that affects children. Treatment involves chemoradiotherapy. This study aimed at evaluating the long-term alterations to teeth and cranial bones in children, teenagers, and young adults after oncologic treatment.<br />Study Design: We conducted a cross-sectional study of patients undergoing treatment for head and neck RMS between 1988 and 2011. We evaluated demographic, clinical, and treatment data and performed panoramic radiography, cephalometry, and photography.<br />Results: We evaluated 27 long-term survivors, most of whom had been treated between ages 0 to 5 years (51.9%). The total radiation dose applied was 50.4 Gy, and the chemotherapy combination included vincristine, actinomycin D, and cyclophosphamide in 51.9% of the cases. We observed 603 dental alterations, among which 377 (62.7%) occurred in patients ages 0 to 5 years, and root shortening was the most frequent alteration observed (24.2%). With regard to facial bones, 74% of the patients had some level of facial asymmetry, 70.4% had reduced facial depth, 48.4% had mandibles of short size, and 77.8% had reduced facial height.<br />Conclusions: Children submitted to RMS treatment involving chemotherapy and radiotherapy displayed significant dental and craniofacial alterations, especially when treatment occurred between ages 0 and 5 years.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
2212-4411
Volume :
127
Issue :
4
Database :
MEDLINE
Journal :
Oral surgery, oral medicine, oral pathology and oral radiology
Publication Type :
Academic Journal
Accession number :
30685390
Full Text :
https://doi.org/10.1016/j.oooo.2018.12.012