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Effect of short-term colchicine treatment on endothelial function in patients with coronary artery disease.
- Source :
-
International journal of cardiology [Int J Cardiol] 2019 Apr 15; Vol. 281, pp. 35-39. Date of Electronic Publication: 2019 Jan 15. - Publication Year :
- 2019
-
Abstract
- Background: Inflammation is associated with endothelial dysfunction and plays an important role in the pathogenesis and development of cardiovascular diseases. It has been shown that colchicine, an anti-inflammatory drug, improves the cardiovascular outcome in patients with cardiovascular disease. The purpose of this study was to evaluate the short-term effect of low-dose colchicine on endothelial function in patients with coronary artery disease (CAD).<br />Methods: This was a double-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 28 patients with CAD received low-dose colchicine (0.5 mg/day) or a placebo for 7 days with a washout period of at least 14 days. Flow-mediated vasodilation (FMD) and serum concentrations of high-sensitivity C-reactive protein (hs-CRP) were measured after the 7-day treatment with colchicine or the placebo.<br />Results: The serum concentration of hs-CRP was significantly decreased after administration of colchicine compared with that after administration of the placebo [median (interquartile range): 0.04 (0.02-0.08) mg/dL vs. 0.07 (0.04-0.11) mg/dL, P = 0.003], while there was no significant difference in FMD between the treatments [median (interquartile range): 3.1% (1.5-5.3%) vs. 3.3% (1.9-5.2%), P = 0.384]. Colchicine, however, significantly improved FMD in coronary artery disease patients with white blood cell (WBC) counts of ≥7500 WBC/mm <superscript>3</superscript> [median (interquartile range): 3.3% (2.1-6.6%) vs. 2.0% (1.4-3.8%), P = 0.043].<br />Conclusions: Administration of low-dose colchicine did not improve endothelial function in patients with CAD, but exploratory analysis suggested that endothelial function is significantly improved in patients with leukocyte activation.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Coronary Artery Disease physiopathology
Cross-Over Studies
Double-Blind Method
Drug Administration Schedule
Endothelium, Vascular drug effects
Female
Gout Suppressants administration & dosage
Humans
Male
Middle Aged
Treatment Outcome
Ultrasonography, Interventional methods
Colchicine administration & dosage
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease drug therapy
Endothelium, Vascular diagnostic imaging
Endothelium, Vascular physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 281
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 30683457
- Full Text :
- https://doi.org/10.1016/j.ijcard.2019.01.054