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Clinical characteristics of a large cohort of patients with positive culture of Fusobacterium necrophorum.

Authors :
Klasinc R
Lupyr K
Zeller I
Paula H
Makristathis A
Tuchmann F
Wrba T
Assadian O
Presterl E
Source :
GMS infectious diseases [GMS Infect Dis] 2018 Mar 07; Vol. 6, pp. Doc03. Date of Electronic Publication: 2018 Mar 07 (Print Publication: 2018).
Publication Year :
2018

Abstract

Background: Fusobacterium necrophorum is a rare pathogen, mostly affecting young adults, causing infections of the head and neck, typically described as the Lemierre's syndrome. Today this symptom complex has become increasingly rare and has almost turned to a 'forgotten disease'. Methods: We performed a retrospective, descriptive study to identify the clinical features of patients with positive culture of F. necrophorum . Additionally, the antibiotic susceptibility profile of the pathogens was analysed. Results: During a period of 22 years 36 patients with at least one isolate of F. necrophorum were identified. Mostly tonsillar and peritonsillar abscesses were found, 10 patients were identified with bacteraemia, but only 4 patients presented with symptoms like sore throat, fever and swollen cervical lymph nodes, which may suggest Lemierre's. Most of the isolates (33/35) showed sensitivity to all tested antibiotics. Conclusion: Appropriate techniques are needed to detect F. necropho rum , especially from throat swabs, in the microbiological laboratory. Current clinical and microbiological practice may lead to under-diagnosis of infections caused by F. necrophorum . Further research is needed to define the colonization rate and to optimize methods for detection as well as identification of virulence.<br />Competing Interests: The authors declare that they have no competing interests.

Details

Language :
English
ISSN :
2195-8831
Volume :
6
Database :
MEDLINE
Journal :
GMS infectious diseases
Publication Type :
Academic Journal
Accession number :
30671334
Full Text :
https://doi.org/10.3205/id000038