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Hypertensive heart disease: Benefit of carvedilol in hemodynamic, left ventricular remodeling, and survival.
- Source :
-
SAGE open medicine [SAGE Open Med] 2019 Jan 08; Vol. 7, pp. 2050312118823582. Date of Electronic Publication: 2019 Jan 08 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Objectives: The aim of this study was to determine if carvedilol improved structural and functional changes in the left ventricle and reduced mortality in patients with hypertensive heart disease.<br />Methods: Blood pressure, heart rate, echocardiographic parameters, and laboratory variables, were assessed pre and post treatment with carvedilol in 98 eligible patients.<br />Results: Carvedilol at a median dose of 50 mg/day during the treatment period in hypertensive heart disease lowered blood pressure 10/10 mmHg, heart rate 10 beats/min, improved left ventricular ejection fraction from baseline to follow-up (median: 6 years) (36%-47%)) and reduced left ventricular end-diastolic and end-systolic dimensions (62 vs 56 mm; 53 vs 42 mm, respectively, all p-values <0.01). Left ventricular ejection fraction increased in 69% of patients. Patients who did not have improved left ventricular ejection fraction had nearly six-fold higher mortality than those that improved (relative risk; 5.7, 95% confidence interval: 1.3-25, p = 0.022).<br />Conclusion: Carvedilol reduced cardiac dimensions and improved left ventricular ejection fraction and cardiac remodeling in patients with hypertensive heart disease. These treatment-related changes had a favorable effect on survival.<br />Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Details
- Language :
- English
- ISSN :
- 2050-3121
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- SAGE open medicine
- Publication Type :
- Academic Journal
- Accession number :
- 30671246
- Full Text :
- https://doi.org/10.1177/2050312118823582