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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
- Source :
-
Nature communications [Nat Commun] 2019 Jan 22; Vol. 10 (1), pp. 376. Date of Electronic Publication: 2019 Jan 22. - Publication Year :
- 2019
-
Abstract
- Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Asian People genetics
Black People genetics
Brazil
Calcium-Binding Proteins genetics
Cholesterol blood
Cholesterol, HDL blood
Cholesterol, HDL genetics
Cholesterol, LDL blood
Cholesterol, LDL genetics
Female
Genome-Wide Association Study
Genotype
Hispanic or Latino genetics
Humans
LIM-Homeodomain Proteins genetics
Lipid Metabolism genetics
Male
Membrane Proteins genetics
Microtubule-Associated Proteins genetics
Middle Aged
Muscle Proteins genetics
Nerve Tissue Proteins genetics
Transcription Factors genetics
Triglycerides blood
Triglycerides genetics
White People genetics
Young Adult
Exercise
Genetic Loci genetics
Lipids blood
Lipids genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 30670697
- Full Text :
- https://doi.org/10.1038/s41467-018-08008-w