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Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation.
- Source :
-
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Apr; Vol. 33 (4), pp. 5237-5247. Date of Electronic Publication: 2019 Jan 22. - Publication Year :
- 2019
-
Abstract
- Increased vitamin A consumption is associated with decreased cortical bone mass and increased fracture risk in humans. Rodent studies have demonstrated that hypervitaminosis A increases cortical bone resorption, whereas the importance of the effects on bone formation is less well defined. We used an experimental model of increased bone formation by loading of the tibiae to investigate the effect of vitamin A on bone formation. Control [retinol activity equivalents (RAE) 4.5 µg/g chow] or vitamin A (RAE 60 µg/g chow) diets were given to female C57BL/6N mice for 4 wk, after which the tibiae were subjected to axial loading on alternate days for 2 wk, while the diets were continued. Vitamin A inhibited the loading-induced increase in trabecular and cortical bone volume. This was attributed to inhibition of loading-induced increase in osteoblast number and activity, and expression of osteoblastic genes Sp7, Alpl, and Col1a1 in cortical bone. Vitamin A, loading, and combination thereof also resulted in site-specific effects on bone composition measured by Raman spectroscopy. In summary, a clinically relevant dose of vitamin A suppresses the loading-induced gain of bone mass by decreasing bone formation. These observations may have implications for regulation of bone mass caused by physical activity and the risk of osteoporosis in humans.-Lionikaite, V., Henning, P., Drevinge, C., Shah, F. A., Palmquist, A., Wikström, P., Windahl, S. H., Lerner, U. H. Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation.
- Subjects :
- Adult
Animals
Bone Density drug effects
Cancellous Bone drug effects
Cancellous Bone physiology
Cortical Bone drug effects
Cortical Bone physiology
Female
Humans
Immunohistochemistry
Mice
Mice, Inbred C57BL
Spectrum Analysis, Raman
Tibia drug effects
Tibia physiology
Tolonium Chloride
Weight-Bearing physiology
Young Adult
Osteogenesis drug effects
Stress, Mechanical
Vitamin A pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6860
- Volume :
- 33
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 30668919
- Full Text :
- https://doi.org/10.1096/fj.201802040R