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Safety and reproducibility of nasal allergen challenge.
- Source :
-
Allergy [Allergy] 2019 Jun; Vol. 74 (6), pp. 1125-1134. Date of Electronic Publication: 2019 Feb 20. - Publication Year :
- 2019
-
Abstract
- Background: The nasal allergen challenge (NAC) is a useful tool for the diagnosis of allergic rhinitis (AR) and local allergic rhinitis (LAR) and might serve to design and monitor allergen immunotherapy. Nevertheless, data about its safety and reproducibility are scarce.<br />Objective: To investigate the safety and reproducibility of NAC in pediatric and adult rhinitis patients with/without asthmatic symptoms, and in healthy controls.<br />Methods: A retrospective evaluation of the NACs conducted in our Unit for 2005-2017 and monitored by acoustic rhinometry and nasal-ocular symptoms was performed to analyze the safety of two methods for allergen application (metered spray & micropipette) and NAC protocols (NAC with single or multiple allergens/session [NAC-S & NAC-M]). The adverse events (AEs), spirometry values, and rescue medication required for AE were recorded. The reproducibility was examined by a prospective analysis of three repeated NAC-S performed at 1-2-month interval in AR, LAR and nonallergic rhinitis patients, and in healthy controls.<br />Results: A total of 11 499 NACs were performed in 518 children and 5830 adults. Only four local AE occurred, and 99.97% of NACs were well tolerated. The reproducibility and positive and negative predictive values of three consecutive NAC-S performed in 710 subjects were 97.32%, 100%, and 92.91%, respectively. There were no false-positive results in the 710 analyzed subjects. Safety and reproducibility were comparable between the methods of allergen application and the rhinitis phenotypes.<br />Conclusion: The NAC is a safe and highly reproducible diagnostic test ready to be used in the clinical practice in both children and adults with or without asthma.<br /> (© 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Allergens administration & dosage
Asthma diagnosis
Bronchial Spasm etiology
Child
Child, Preschool
Female
Humans
Male
Middle Aged
Prospective Studies
Reproducibility of Results
Retrospective Studies
Rhinometry, Acoustic
Young Adult
Allergens immunology
Nasal Provocation Tests adverse effects
Nasal Provocation Tests methods
Rhinitis, Allergic diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1398-9995
- Volume :
- 74
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 30667530
- Full Text :
- https://doi.org/10.1111/all.13728