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Copper-Catalyzed Oxidative sp 3 -Carbon Radical Cross-Coupling with Trialkylphosphites Leading to α-Phosphonyl 1,3-Dicarbonyl Compounds.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2019 Feb 15; Vol. 84 (4), pp. 2351-2357. Date of Electronic Publication: 2019 Feb 04. - Publication Year :
- 2019
-
Abstract
- A copper-catalyzed radical C <subscript>sp <superscript>3</superscript> </subscript> -H/P(OR) <subscript>3</subscript> cross-coupling reaction for the formation of C <subscript>sp <superscript>3</superscript> </subscript> -P bonds is described. A range of 1,3-dicarbonyl compounds and trialkylphosphites were coupled in this fashion to give the corresponding products in moderate to good yields. This protocol provides direct access to α-phosphonyl 1,3-dicarbonyl compounds.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 84
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 30667228
- Full Text :
- https://doi.org/10.1021/acs.joc.8b03093