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An online resource for GPCR structure determination and analysis.
- Source :
-
Nature methods [Nat Methods] 2019 Feb; Vol. 16 (2), pp. 151-162. Date of Electronic Publication: 2019 Jan 21. - Publication Year :
- 2019
-
Abstract
- G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into appropriate cellular responses and mediate the actions of one-third of drugs. GPCR structural studies have revealed the general bases of receptor activation, signaling, drug action and allosteric modulation, but so far cover only 13% of nonolfactory receptors. We broadly surveyed the receptor modifications/engineering and methods used to produce all available GPCR crystal and cryo-electron microscopy (cryo-EM) structures, and present an interactive resource integrated in GPCRdb ( http://www.gpcrdb.org ) to assist users in designing constructs and browsing appropriate experimental conditions for structure studies.
- Subjects :
- Allosteric Site
Animals
Cattle
Cryoelectron Microscopy
Crystallography, X-Ray
Databases, Protein
Drug Design
Glycosylation
HEK293 Cells
Humans
Mutation
Phosphorylation
Protein Domains
Protein Engineering
Rhodopsin chemistry
Signal Transduction
Software
Computational Biology methods
Internet
Receptors, G-Protein-Coupled genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1548-7105
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nature methods
- Publication Type :
- Academic Journal
- Accession number :
- 30664776
- Full Text :
- https://doi.org/10.1038/s41592-018-0302-x