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An online resource for GPCR structure determination and analysis.

Authors :
Munk C
Mutt E
Isberg V
Nikolajsen LF
Bibbe JM
Flock T
Hanson MA
Stevens RC
Deupi X
Gloriam DE
Source :
Nature methods [Nat Methods] 2019 Feb; Vol. 16 (2), pp. 151-162. Date of Electronic Publication: 2019 Jan 21.
Publication Year :
2019

Abstract

G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into appropriate cellular responses and mediate the actions of one-third of drugs. GPCR structural studies have revealed the general bases of receptor activation, signaling, drug action and allosteric modulation, but so far cover only 13% of nonolfactory receptors. We broadly surveyed the receptor modifications/engineering and methods used to produce all available GPCR crystal and cryo-electron microscopy (cryo-EM) structures, and present an interactive resource integrated in GPCRdb ( http://www.gpcrdb.org ) to assist users in designing constructs and browsing appropriate experimental conditions for structure studies.

Details

Language :
English
ISSN :
1548-7105
Volume :
16
Issue :
2
Database :
MEDLINE
Journal :
Nature methods
Publication Type :
Academic Journal
Accession number :
30664776
Full Text :
https://doi.org/10.1038/s41592-018-0302-x